Pregnant Woman with Markedly Increased Iron Binding Capacity

Pregnant woman with markedly increased iron binding capacity.

1 Department of Pathology and Laboratory Medicine, Santa Clara Valley Medical Center, San Jose, CA. * Address correspondence to this author at: Santa Clara Valley Medical Center, Department of Pathology and Laboratory Medicine, 751 S. Bascom Ave, San Jose, CA 95128. E-mail [email protected]. Received October 1, 2014; accepted December 11, 2014. DOI: 10.1373/clinchem.2014.234229 © ...

A 72-year-old woman with markedly increased ferritin.

CASE DESCRIPTION A 72-year-old woman with a history of adult-onset Still disease and congestive heart failure was transferred from an outside hospital. She had a 2-week history of fevers, diarrhea, nausea, sore throat, and myalgias. At presentation, she had a markedly increased plasma ferritin concentration [238380 ng/mL (reference intervals shown in Table 1)], low hemoglobin (7.2 g/dL), hypert...

iron-binding capacity

SYNOPSIS A method is described for measuring the plasma unsaturated iron-binding capacity in the presence of very high concentrations of iron as iron-dextran. The procedure utilizes 59Fe to label the apotransferrin with subsequent separation of ionic iron from transferrin-bound iron on an ion exchange or Sephadex G.25 column. The unsaturated iron-binding capacity has been measured in rabbits an...

A Pregnant Woman with Factor V Deficiency

transferrin by iron-binding capacity

SYNOPSIS Two criteria which ought to be satisfied by an acceptable method for the estimation of serum transferrin by iron-binding capacity are enunciated. A screening procedure is described which involves the sequential quantitative use of ion exchange and gel filtration. Its use in testing the extent to which two published methods fulfil the recommended criteria is described. Both methods give...